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Nnamani, P. O.
- Studies on Diclofenac -β- Cyclodextrin Inclusion Complexes
Abstract Views :177 |
PDF Views:76
Authors
Affiliations
1 Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, NG
1 Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, NG
Source
Journal of Pharmaceutical Research, Vol 3, No 3 (2004), Pagination: 47-49Abstract
This work was aimed at investigating diclofenac-β-cyclodextrin inclusion complexes in aqueous medium. Applying the method of phase solubility analysis, β-cyclodextrin formed a complex in 1:1 stoichiometry with diclofenac. The complex obeyed Beer's law. The stability constant, partition coefficient and solubility values were evaluated. The effect of pH on the stability of the complex was studied. The results indicated an increased aqueous solubility of diclofenac when complexed with β-cyclodextrin. Maximum stability of the complex was at pH value of 4.0. This makes it possible for aqueous oral solution of diclofenac to be formulated.Keywords
Cyclodextrin, Inclusion Complex, Stability, Diclofenac, Phase Solubility.Full Text
- Polyelectrolyte Complexes of Irvingia gabonensis Gum and Gelatin:Performance of Suspended Chalk Particles
Abstract Views :195 |
PDF Views:80
Authors
Affiliations
1 Drug Delivery Research Unit, Department Of Pharmaceutics University Of Nigeria, Nsukka (410 001), Enugu State, NG
1 Drug Delivery Research Unit, Department Of Pharmaceutics University Of Nigeria, Nsukka (410 001), Enugu State, NG
Source
Journal of Pharmaceutical Research, Vol 9, No 3 (2010), Pagination: 117-121Abstract
The suspending properties of the polyelectrolyte complexes (PECs) or co-precipitates from Ogbono gum, (Irvingia gabonensis, variety excels, Fam. Irvingiaceae) and gelatin were carried out. The gum was extracted, co-precipitated with gelatin and used to prepare chalk suspension. Parameters determined were as follows: sedimentation rate, viscosity, pH, redispersibility number and effect of electrolytes on the rheology of the suspension. The result was compared with that of a commercial brand of Mist Magnesium trisilicate (Product X) obtained from Gloria, G Pharmaceuticals, Nigeria Limited. The results of the study credited Irvingia gabonensis gum as being a better suspending agent alone than gelatin. In furtherance, the PECs-containing suspension prepared with 1:4 combination of gelatin and Irvingia gabonensis gum had the best properties in relation to the assessed parameters as being the best viscosity impacting agent with the least redispersibility number which is a marker to its suspension not forming cake upon storage as well as making for easy re-suspension of sedimented particles and ensuring accurate dosing superior to the Product X.Keywords
Polyelectrolyte Complexes, Irvingia gabonensis, Gelatin, Chalk, Suspension.Full Text